3-Amino-4-pyrazole carbosamide hemisulfate

Fa'asao mo le tu'ufa'atasiga o le allopurinol.

O se tasi lea o le 3-amino-4-substituted pyrazole series.E mafai ona faʻaaogaina e avea o se vaeluagalemu e faʻapipiʻi ai le tele o vailaʻau faʻapitoa faʻapitoa, e pei o le allopurinol, o se tasi o le pyrazolopyrimidine derivatives series, o le mulimuli talu mai le 1963 Talu mai lona faʻaogaina i le falemaʻi, o le vailaʻau autu mo le togafitiga o le gout.I le taimi nei, e itiiti lava auala iloa mo le faʻapipiʻiina

3-aminopyrazole-4-carboxamide hemisulfate i Saina, e masani lava e ala i le tali malononitrile ma triethyl orthoformate e saunia ethoxymethylene malononitrile, ona sosoo ai lea ma le O le tali atu o le hydrazine hydrate e maua ai le 3-amino-4-cyanopyrazole, lea e iu lava ina faʻafefeteina ma le faʻamaʻi faʻamaʻi e maua ai le faʻamaʻi faʻamaʻi.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), o le aofaʻi o fua o le faʻapipiʻi e ala i lenei metotia e tusa ma le 60% (faʻatusatusaina o le malononitrile), o lenei metotia E aofia ai se tali e tolu-laasaga, o laʻasaga e umi, ma o mea faʻaaogaina, e pei o le malononitrile ma le ethoxymethylene malononitrile, e sili atu ona oona ma taugata.E le gata i lea, o le 3-aminopyrazole-4 ua saunia e lenei metotia -Formamide hemisulfate o loʻo i ai se lanu e faigata ona aveese ma manaʻomia ai le faʻaogaina atili, lea e sili atu ona faigata.

O loʻo i ai lipoti i tusitusiga mai fafo e faʻaaoga ai le pyridylamide hydrazone ma le ethoxymethylene malononitrile e avea ma mea mataʻutia e maua ai le 3-amino-4-cyanopyrazole e ala i le faʻaopoopoga ma le cyclization, ona tali atu lea i le sulfuric acid concentrated e maua ai le faʻapipiʻi sini (Reuken G Jones. Reactions of orthoesters with activemethylene compounds [J] J Am Chem Soc. 1952,74(5):4889 4891).O mea autu autu o loʻo faʻaaogaina i lenei metotia e taugata, o le gaioiga o le gaioiga e le maualuga, ma o le tupe mama o le gaosiga o pisinisi e maualalo.E tatau ona faigata.