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5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-tasi hydrochloride

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-tasi hydrochloride

Fa'amatalaga Puupuu:

CAS no:115473-15-9

Mea tau vaila'au: Prasugrel Intermediates


Fa'amatalaga Oloa

Faailoga o oloa

Fa'aoga

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-one hydrochloride o loʻo faʻaaogaina e fai ma sui o Prasugrel.

O le Prasugrel o se thiophenopyridine antiplatelet na fausia e Eli Lilly ma daiichisankyo, o se fale gaosi oloa Iapani.O se vailaau muamua.E fausia ai se mole malosi pe a maeʻa le metabolism e ala i le cytochrome P450 i le ate ma tuʻufaʻatasia ma le platelet P2Y12 receptor e faʻamalosi malosi e faasaga i platelet aggregation.O suʻesuʻega faʻapitoa ua faʻamaonia ai o le 60 mg dose e sili atu le aʻafiaga o le anticoagulant nai lo le 300 mg standard dose ma le 600 mg faʻateleina le fua o le clopidogrel, lea e mafai ona faʻaitiitia ai le lamatiaga atoatoa o le fatu fatu, stroke ma le oti ona o le fatu fatu e 20%, ma e vave ona aʻafia. , a'afiaga fa'amalolo lelei, fa'ato'aga lelei o vaila'au ma le bioavailability, ma maualalo le o'ona.


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