Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];Ata Fa'apitoa](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
Caspofungin Acetate Biological Activity
| Faamatala | Caspofungin Acetate o se vailaʻau faʻamaʻi e le mafai ona faʻatauvaʻa le faʻaogaina o le 1,3-β-d glucan synthase. |
| Fa'atatauvaega | ala fa'ailo >> Anti-fa'ama'i >> Agi Nofoaga su'esu'e >> A'afia |
| I vivosu'esu'ega | O isumu na tui i le caspofungin e leai ni suiga taua i la latou galu ERG i le vitreous concentration o le 0.41 i le 4.1 μM, ma o latou retina e leai ni suiga o le morphological poʻo le leiloa o le cell.I le vitreous concentration o le 41 μM, o le caspofungin na faʻaitiitia ai le maualuga o le galu, b ma le scotopic threshold tali a le ERG, ma mafua ai foi le faʻaitiitia o le numera o sela i le ganglion cell layer [1].Carprofungin (8 mg/kg) poʻo le amphotericin B 1 mg/kg, tui intraperitoneal tasi i le aso 30 h pe a uma faʻamaʻi mo le 7 aso sosoo, e faʻatatau i le faʻatonutonuina o taavale, 100% ola i le aso 28, e mafua ai le 100% o le oti i le ao 11 , ina ua uma lu'i pipisi.Pe a faʻatusatusa i le togafitiga o le taʻavale i le aso 5, o le caspofungin na faʻaitiitia le toe faʻaleleia o le Candida ola i totonu o fatugaʻo ma faiʻai pe a oʻo i le maualuga o le avega.O isumu na togafitia i le caspofungin i se fua o le 2 mg / kg poʻo le maualuga e sili atu le maualalo o le faiʻai i le aso 5 nai lo isumu na togafitia i le amphotericin B. Amphotericin B ma le caspofungin na faʻaitiitia ai le mamafa o le fatu i le 1.7 log CFU / g ma le 2.46 i le 3.64 log CFU. /g, fa'asologa [2]. |
| Manufa'ata'ita'iga | O togafitiga faʻamaʻi na amata ile 30 itula talu ona maeʻa le faʻamaʻi pipisi ma tuʻuina atu ile tui ole intraperitoneal (ip) tasi ile aso mo le 7 aso.Na togafitia isumu i le 1, 2, 4, poʻo le 8 mg / kg / aso caspofungin, 1 mg / kg / aso amphotericin B poʻo le taʻavale (vai faʻafefeteina).O le aoga o le faʻataʻitaʻiga na iloiloina i ni auala se tolu: e ala i le mataʻituina o le ola o le 10 manu i vaega taʻitasi togafitiga, e ala i le mataʻituina o le uta Candida i le fatugaʻo ma le faiʻai o le vaega lona lua o manu togafitia, ma le suʻesuʻeina o fatugaʻo.Ma fai'ai.O le vaega lona tolu o manu ua togafitia.O isumu na faʻaumatia e le CO 2 inhalation ma faʻatupuina i le 30 itula (naʻo le pulea o taavale) ma le aso 5 (24 itula i le maeʻa ai o le 4th dose), 8 (24 itula talu ona maeʻa le tui mulimuli), ma le 14, 21 itula Ma histological. fa'ata'ita'iga o mea'ai.(Naʻo le caspofungin togafitiga), ma le 28 ina ua uma le osofaʻiga. |
| Fa'asinomaga | [1].Mojumder DK, et al.Su'esu'eina o le o'ona o le intravitreal caspofungin i le mata isumu.Investiga Ophthalmol Vis Sci.2010 Nov;51(11):5796-803. [2].Fa'ase'e, Amy M. et al.O le aoga o le caspofungin i se faʻataʻitaʻiga o le isumu o le fatugalemu o le candidiasis.Antimicrobial Agents and Chemotherapy (2011), 55(7), 3491-3497. |
O mea tau vaila'au ma fa'aletino ole caspofungin acetate
| Fa'apuna | 1408.1ºC ile 760 mmHg |
| fua mole | C56H96N10O19 |
| mamafa mole | 1093.31000 |
| Tulaga sa'o | 1092.64000 |
| PSA | 412.03000 |
| LogP | 0.06150 |
| Uiga foliga | paepae i le beige |
| Omiga ausa | 0mmHg ile 25°C |
| Tulaga teuina | 20°C |
| Suavai soluble | H2O: soluble15mg/mL (fofo manino) |
Caspofungin Acetate Tiute
| Tulafono a le Ofisa o Tiute | 2933990099 |
| Vaaiga Fa'aSaina | 2933990099. O isi fa'apotopotoga fa'ata'ita'i o lo'o i ai na'o le nitrogen heteroatoms.Lafoga fa'aopoopo o tau: 17.0%.Lafoga toe fa'aitiitiga: 13.0%.Tulaga fa'atonutonu: Leai.Totogi sili ona fiafia i ai le atunuu: 6.5%.Totogi lautele: 20.0% |
| Elemene ta'utinoga | Igoa o oloa, mea e aofia ai, faʻaoga, hexamethylene chloride, faʻamolemole faʻaalia foliga vaaia, 6-caprolactam, faʻamolemole faʻaalia foliga vaaia, aso saini |
| Aotelega | 2933990090. fa'atasiga fa'agata fa'atasi ma na'o le fa'aato-atoma.VAT:17.0%.Lafoga fa'aitiitiga fua faatatau:13.0%..MFN tau:6.5%.Totogi lautele:20.0% |
Gaosiga Fa'agasologa
Caspofungin e manaʻomia ona saunia e ala i le faʻafefeteina o tekinolosi semi-synthetic.O le oloa mama o le mama autu e tatau ona maua e ala i tekinolosi fermentation, ona maua ai lea o le oloa vaeluaga e ala i le vavaeeseina ma le faamamaina, ona faʻaaogaina lea o le oloa vaeluaga e avea ma mea amata e faʻamaeʻa ai le faʻaogaina o le filifili o le itu e faʻaaoga ai tekinolosi faʻapipiʻi e iu lava ina maua. le Elemene taula'i.Ona o oloa "fermented semi-synthetic" e manaʻomia ona ui atu i le tele o fesoʻotaʻiga faʻapitoa e pei o le faʻafefeteina, vavaeeseina ma le faʻamamāina, faʻasologa, ma isi, o le auala faʻapitoa ma le faʻatonutonuina o le faʻagasologa e matua faigata lava i Chemicalbook.E le gata i lea, o manaʻoga faʻatulafonoina mo le resitalaina o le caspofungin, o se oloa semi-synthetic faʻafefeteina, e matua maualuga lava.O pepa talosaga e mana'omia e amata mai i le puna fa'afefete, e le gata ina su'esu'e fa'aleaogaina le fa'ato'aga fa'ato'aga, fa'atekonolosi fa'avela, ma le fa'amamāina o tekonolosi, ae ia su'esu'e fo'i le fa'agasologa o le fa'asologa.Auala, tulaga, ma le puleaina o mea le mama i le faagasologa, ona o le oloa mulimuli e fai si maaleale, soʻo se faʻatamala o le a soloiesea uma taumafaiga muamua, ma le faigata faʻapitoa ma tau e le taua.
E mafua ona o le maualuga o pa puipui faʻapitoa ma se tulaga faʻatauvaʻa lelei na faʻatumauina ai e Hengrui Caspofungin se tau lelei tele pe a maeʻa lana lisi.
Na muta le puipuiga o pateni i le 2014
Fa'atauina o tui fa'agata caspofungin i falema'i lautele i Saina (iunite: sefulu afe yuan)
E o'o mai i le taimi nei, na'o vaila'au lautele a Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, ma Haisco ua fa'amaonia mo le lisiina.Huadong Vailaau?
O le uluai kamupani su'esu'e o le caspofungin acetate o Merck, ma o le lisi o talosaga a kamupani e 6 o lo'o iloiloina ma fa'amaonia, e ta'ua o Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, ma Tian Wei Biopharmaceuticals.
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FA'ATAITAI O GALUEGA
●Mata'u maualuga Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
●Toe Fa'atonuga
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Meafaigaluega
O loʻo i ai i la matou Fale suʻesuʻe mea faʻapitoa ma suʻega, e pei o le: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
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Ua matou fesoasoani i nisi o kamupani pito i luga ole fale talavai, pei oleHansoh, Hengrui ma HEC Pharm.O iinei o le a tatou faaali atu ai se vaega o latou.
Fa'asinomaga Tulaga Muamua:
Kase Numera: 110351-94-5
Tulaga Fa'apitoa Lua:
Cas Nu.: 144848-24-8
Tulaga Fa'apitoa Tolu:
Cas Nu.: 200636-54-0
1.Fa'asinomaga Fou Intermediates po'o API.E tutusa ma le faʻasoaina o mataupu i luga, o loʻo i ai i tagata faʻatau manaʻoga mo Intermediates patino poʻo API, ma e le mafai ona latou mauaina oloa manaʻomia i le maketi, ona mafai lea ona matou fesoasoani i le Customize.
2.Fa'atonuga Fa'agasologa mo Oloa Tuai.O la matou 'au o le a fesoasoani i le fa'aleleia ma le fa'aleleia o ia gaosiga o lo'o tuai ai le auala e tali mai ai, e maualuga le tau o gaosiga, ma e maualalo le lelei.E mafai ona matou tuʻuina atu faʻamaumauga atoa mo le faʻaaogaina o tekonolosi ma le faʻaleleia atili o le faagasologa, fesoasoani i tagata faʻatau mo se gaosiga sili atu.
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