Rivaroxaban（S)-Rivaroxaban;BAY 59-7939;RivaroxabanIsomer;Rivaroxaban;
Rivaroxaban（S)-Rivaroxaban;BAY 59-7939;RivaroxabanIsomer;Rivaroxaban;
Fa'aaogaina i tagata matutua e iai le taotoga suilapalapa po'o tulivae e puipuia ai le thrombosis venous (VTE).
E faʻaaogaina e puipuia pe faʻaitiitia ai le faʻavaeina o le thrombosis, loloto vein thrombosis (DVT) ma le pulmonary embolism (PE) pe a uma le taotoga suilapalapa poʻo tulivae.
Ole fua fautuaina ole rivaroxaban ole 10mg, tasi ile aso.Rivaroxaban 10mg e mafai ona ave faʻatasi ma meaʻai pe naʻo oe.Rivaroxaban 15mg poʻo le 20mg tablets e tatau ona ave faʻatasi ma meaʻai.
tulaga masani: usp40
Su'ega: 99-102%
I fafo: Pa'epa'e pa'epa'e
afifi: 25kg/pa'u
Ave 4-(4-aminophenyl) morpholin-3-one (SM-1), (S)-N-glycidyl phthalimide (SM-2), 5-chlorothiophene-2- Formyl chloride (SM-3) o le mea amata. .A maeʻa le condensation, cyclization, aminolysis ma le acylation, e maua le rivaroxaban crude, ma faʻamamaina le rivaroxaban maeʻa.
Sauniuniga: O lenei oloa o se laupepa mumu e ufiufi i ata tifaga.
Mea fa'aoga:
O le autu o le laulau: microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, hypromellose, sodium lauryl sulfate, magnesium stearate
Ufiufi: polyethylene glycol, hypromellose, titanium dioxide, iron oxide mumu
Rivaroxaban o se vailaʻau sili ona filifilia, tautala e faʻalavelave tuusaʻo le Xa.E ala i le filifilia ma le faʻatauvaʻa faʻasaina o le fua ma fusifusia mea Xa ma le prothrombin gaioiga, faʻaumiumi le faʻagaoioia vaega o le thromboplastin time plate (PT) ma le prothrombin time (aPTT) i se fua faʻalagolago, lea e mafai ona faʻalavelaveina le afu coagulation O auala faʻamaʻi ma fafo. taofia le gaosiga o le thrombin ma le thrombosis.Rivaroxaban e le fa'alavelaveina le thrombin (fa'agaoioi vaega Ⅱ), pe fa'amaonia e iai sona a'afiaga i platelets.
O le eseesega taua i le va o le rivaroxaban ma le fondaparinux / heparin e le manaʻomia ai le auai o le antithrombin III ma e mafai ona faʻafeagai saʻo fua ma fusifusia mea Xa;a'o le heparin e mana'omia le antithrombin III e galue, ma e leai sona a'afiaga i le mea Xa i le prothrombin lavelave.
JIN DUN Medical uaFa'ailoga ISO ma fa'amalieina tulaga fa'atupu GMP, fa'afaigaluegaina tagata tomai faapitoa i le fa'aogaina o vaila'au i totonu ma fafo ma le poto masani e ta'ita'ia le R&D a le kamupani.
FA'ATAITAI O GALUEGA
●Mata'u maualuga Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
●Toe Fa'atonuga
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Meafaigaluega
O loʻo i ai i la matou Fale suʻesuʻe mea faʻapitoa ma suʻega, e pei o le: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
Vaega su'esu'e
Jindun Medical ei ai se vaega o tagata faigaluega R & D faʻapolofesa, ma faʻafaigaluegaina le tele o tagata tomai faʻapitoa mo vailaʻau faʻapitoa i totonu ma fafo e taʻitaʻia le R&D, ma faʻafaigofie atili ma lelei a tatou faʻasologa.
Ua matou fesoasoani i nisi o kamupani pito i luga ole fale talavai, pei oleHansoh, Hengrui ma HEC Pharm.O iinei o le a tatou faaali atu ai se vaega o latou.
Fa'asinomaga Tulaga Muamua:
Kase Numera: 110351-94-5
Tulaga Fa'apitoa Lua:
Cas Nu.: 144848-24-8
Tulaga Fa'apitoa Tolu:
Cas Nu.: 200636-54-0
1.Fa'asinomaga Fou Intermediates po'o API.E tutusa ma le faʻasoaina o mataupu i luga, o loʻo i ai i tagata faʻatau manaʻoga mo Intermediates patino poʻo API, ma e le mafai ona latou mauaina oloa manaʻomia i le maketi, ona mafai lea ona matou fesoasoani i le Customize.
2.Fa'atonuga Fa'agasologa mo Oloa Tuai.O la matou 'au o le a fesoasoani i le fa'aleleia ma le fa'aleleia o ia gaosiga o lo'o tuai ai le auala e tali mai ai, e maualuga le tau o gaosiga, ma e maualalo le lelei.E mafai ona matou tuʻuina atu faʻamaumauga atoa mo le faʻaaogaina o tekonolosi ma le faʻaleleia atili o le faagasologa, fesoasoani i tagata faʻatau mo se gaosiga sili atu.
Mai fuala'au fa'atatau ile INDs, JIN DUN Medical e tu'uina atu ia te oefofo R&D fa'apitoa e tasi taofi.
JIN DUN Fomaʻi faʻamalosi i le fatuina o se 'au ma miti, faia o oloa mamalu, faʻaeteete, malosi, ma alu uma e avea ma paaga faʻalagolago ma uo a tagata faʻatau!
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